Effects of Valine-5 Angiotensin II on Excretion of Water and Salt in Primary and Secondary Hypertension.

Abstract

Valine-5 angiotensin II was administered at rates of 0.3 to 0.6 [mu]g/min. over 6 to 24 hours to 6 subjects with hypertension of various etiologies under conditions of positive and negative Na balance. The effect of angiotensin on Na and water excretion was determined by the state of Na balance regardless of the etiology of the hypertension. In patients in positive Na balance angiotensin promoted natriuresis and diuresis. The effect was greatest in those subjects with a diastolic blood pressure above 110 mm Hg. In Na depleted patients angiotensin tended to produce a diminished excretion of salt and water.