Prevention of Acute Immunological Lung Change by Previously Induced Acute Uremia in Rats

Abstract

Acute experimental uremia in rats prevented the development of the acute lung changes due to intravenous injection of nephrotoxic immune serum. According to previous evidence such pulmonary lesions, regularly observed in non-uremic control rats, should be regarded as the result of an immunological reaction. Acute uremia caused no structural change in the lungs that could obviously hinder the contact between circulating antibodies and local antigens. Again plasma complement was normal. It is suggested that acute uremia interferes with some final mechanism through which the inflammation secondary to antibody-tissue antigen reaction is brought about.