Neuronal Differentiation in Human Fetal Adrenal Medulla

Abstract
The human fetal adrenal medulla evidently contains a pool of primitive sympathetic elements, which possess the capacity for differentiation to both catecholamine storing medullary cells and neurons. Furthermore, these cells are organized into large, rounded, tightly packed avascular cell islands which were easily found and/or isolated. The purpose of the present study was to follow the development of primitive sympathetic cells in human fetal adrenal medulla to find the origin of the adrenal neurons.