α-Methylphenylalanine, a New Inducer of Chronic Hyperphenylalaninemia in Suckling Rats
- 4 June 1976
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 192 (4243), 1007-1008
- https://doi.org/10.1126/science.944951
Abstract
Alpha-Methylphenylalanine reduces the phenylalanine hydroxylase activity of rat liver by 75 percent. Daily injections of this substance (plus phenylalanine) into rats from the 3rd to 15th day of age had no obvious toxic effects, and maintained a plasma concentration of phenylalanine comparable to that of phenylketonuric subjects.This publication has 3 references indexed in Scilit:
- Effect of Phenylalanine and p-Chlorophenylalanine Administration on the Development of Rat Brain 2',3'-Cyclic Nucleotide 3'-PhosphohydrolaseExperimental Biology and Medicine, 1974
- The quantitative determination of phenylalanine hydroxylase in rat tissues. Its developmental formation in liverBiochemical Journal, 1972
- p -Chlorophenylalanine-Induced Chemical Manifestations of Phenylketonuria in RatsScience, 1967