The selective localization of B lymphocytes in the spleen and the role of complement receptors
- 1 January 1985
- journal article
- research article
- Published by Wiley in European Journal of Immunology
- Vol. 15 (7), 681-686
- https://doi.org/10.1002/eji.1830150708
Abstract
The role of complement receptors on the localization of T and B cells in the spleen of mice was studied using short‐term homing experiments in cobra venom factor (CoF)‐ treated animals. The localization ratio of B and T cells in the spleen of CoF‐treated mice decreased significantly compared to control recipients. No changes could be found in the relative distribution of resident T and B cells in the spleen or other lymphoid organs of CoF‐treated animals and when their spleen or lymph node cells were transferred, the localization pattern was normal. When cells were incubated in serum prior to transfer a disturbed localization ratio in the spleen of untreated recipients was observed. This was due to a blockade of complement receptors as determined by the inability of the incubated cells to form EAC rosettes. No blockade of EAC rosettes and no changes in localization ratios upon transfer could be observed when the cells were incubated in functionally C3‐depleted serum. The results suggest a role for the complement‐receptor on B cells in the initial localization in the spleen, whereas no influence upon the selective localization in high endothelial venules‐ bearing organs was found.This publication has 34 references indexed in Scilit:
- C3 Cleaved by Membrane Proteases Binds to C3b Acceptors Expressed on Concanavalin A‐Stimulated Human Lymphocytes and Enhances Antibody‐Dependent Cellular CytotoxicityScandinavian Journal of Immunology, 1984
- Cellular receptors for fragments of the third component of complementImmunology Today, 1984
- Different macrophage populations distinguished by means of fluorescent polysaccharides. Recognition and properties of marginal‐zone macrophagesEuropean Journal of Immunology, 1981
- Organ specificity of lymphocyte migration: mediation by highly selective lymphocyte interaction with organ‐specific determinants on high endothelial venulesEuropean Journal of Immunology, 1980
- Studies on the mechanism of the complement-mediated inhibition of the Fc and C3 receptors of B lymphocytesClinical Immunology and Immunopathology, 1977
- Comparative migration of B- and T-lymphocytes in the rat spleen and lymph nodesCellular Immunology, 1976
- Control mechanism of lymphocyte traffic. Altered distribution of 51Cr‐labeled mouse lymph node cells pretreated in vitro with lipopolysaccharideEuropean Journal of Immunology, 1976
- Immunosuppression by cobra factor: Distribution, antigen-induced blast transformation and trapping of lymphocytes during in vivo complement depletionCellular Immunology, 1976
- HOMING PROPERTIES OF THYMUS-INDEPENDENT FOLLICULAR LYMPHOCYTESTransplantation, 1973
- A POPULATION OF LYMPHOCYTES BEARING A MEMBRANE RECEPTOR FOR ANTIGEN-ANTIBODY-COMPLEMENT COMPLEXESThe Journal of Experimental Medicine, 1970