HEMATOPOIETIC STRESS AND FETAL HEMOGLOBIN-SYNTHESIS - COMPARATIVE STUDIES INVIVO AND INVITRO
- 1 January 1979
- journal article
- research article
- Vol. 54 (5), 1176-1181
Abstract
Baboons exposed to acute hemolytic stress increased their production of fetal Hb (HbF). Although the maximal in vivo HbF levels attained in 5 treated animals varied from 6.4-34.8%, their cultured bone marrow erythroid cells reverted to the fetal pattern of Hb synthesis. HbF synthesis is apparently modulated by the interaction of inhibiting and promoting factors, which is different among animals in vivo but equal in the cultures of their bone marrow erythroid cells.This publication has 5 references indexed in Scilit:
- The structure of hemoglobin Indianapolis [beta112(G14) arginine]. An unstable variant detectable only by isotopic labeling.Journal of Biological Chemistry, 1979
- Stimulation of fetal hemoglobin synthesis in baboons by hemolysis and hypoxia.Proceedings of the National Academy of Sciences, 1978
- CONSISTENT ACTIVATION OF FETAL HEMOGLOBIN SYNTHESIS IN CULTURED ADULT BONE-MARROW CELLS1978
- Human marrow erythropoiesis in culture: II. Heterogeneity in the morphology, time course of colony formation, and sedimentation velocities of the colony-forming cellsAmerican Journal of Hematology, 1976
- A MODEL FOR THE PERSISTENCE OR REACTIVATION OF FETAL HqMOGLOBIN PRODUCTIONThe Lancet, 1976