Platelet‐derived growth factor stimulates the phosphorylation of ribosomal protein S6
- 30 May 1983
- journal article
- Published by Wiley in FEBS Letters
- Vol. 156 (1), 130-134
- https://doi.org/10.1016/0014-5793(83)80263-4
Abstract
The human platelet derived-growth factor (PDGF) is both a potent mitogen and a strong chemoattractant protein for cells involved in inflammation and repair. In seeking mechanisms by which PDGF might initiate specific activities in target cells, it was found that highly purified PDGF stimulates the phosphorylation of an M r ∼33 000 protein in confluent Swiss mouse 3T3 cells [Biochem. Biophys. Res. Commun. (1981) 103, 355–361]. The M r ∼ 33 000 protein has now been recovered in polysomes by differential centrifugation and identified as ribosomal protein S6 by two-dimensional polyacrylamide gel electrophoresis.Keywords
This publication has 33 references indexed in Scilit:
- Chemotactic activity of platelet alpha granule proteins for fibroblasts.The Journal of cell biology, 1983
- Chemotaxis of monocytes and neutrophils to platelet-derived growth factor.JCI Insight, 1982
- Stimulation of tyrosine-specific phosphorylation by platelet-derived growth factorNature, 1982
- Stimulation of protein phosphorylation in Swiss mouse 3T3 cells by human platelet derived growth factorBiochemical and Biophysical Research Communications, 1981
- Nerve growth factor mediates phosphorylation of specific proteinsCell, 1980
- Regulation of 40S ribosomal protein S6 phosphorylation in Swiss mouse 3T3 cellsCell, 1980
- Abelson murine leukaemia virus protein is phosphorylated in vitro to form phosphotyrosineNature, 1980
- The Structure and Function of Eukaryotic RibosomesAnnual Review of Biochemistry, 1979
- Insulin‐like growth factor: insulin or serum increase phosphorylation of ribosomal protein S6 during transition of stationary chick embryo fibroblasts into early G1 phase of the cell cycleFEBS Letters, 1979
- Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4Nature, 1970