Serum and Cerebrospinal Fluid Enzymes in Cerebrovascular Disease

Abstract

THE clinical significance of enzymology in neurological disorders is as yet uncertain. A number of enzymes have been studied both in serum and in cerebrospinal fluid (CSF). In general, these studies have been limited to a single enzyme and have not included a comparison of the serum and CSF activities of the same enzymes.^1-12Much more needs to be known about the levels of different enzymes in CSF, their relation with one another, and their relation to the serum levels of the same enzymes. In the present study, we compare the CSF and serum activities of the enzymes creatine phosphokinase (CPK), lactic dehydrogenase (LDH), and aldolase (ALD) in a series of patients suffering from acute vascular disorders of the brain. These enzymes are well-known in clinical enzymology and have been studied to some extent in the CSF. CPK in particular is an attractive enzyme because it is found