Progressive Loss of β-Cell Function Leads to Worsening Glucose Tolerance in First-Degree Relatives of Subjects With Type 2 Diabetes
Open Access
- 1 March 2007
- journal article
- Published by American Diabetes Association in Diabetes Care
- Vol. 30 (3), 677-682
- https://doi.org/10.2337/dc06-1834
Abstract
OBJECTIVE—The relative roles of insulin resistance and β-cell dysfunction in the pathogenesis of impaired glucose tolerance (IGT) and type 2 diabetes are debated. First-degree relatives of individuals with type 2 diabetes are at increased risk of developing hyperglycemia.Keywords
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