Immediate Effects of Epinephrine on Phospholipides Turnover and Lipide Partition in Plasma, Liver and Aorta

Abstract

The lipids partition and phospholipids turnover in plasma, liver and aorta of intact rabbits was determined 6 hours after subcutaneous injection of 1 mg/kg of epinephrine in oil. Significant changes were found in liver total lipid, ester cholesterol and neutral fat concentrations, and the plasma phospholipid level; but no alterations in the concentration of the different aortic lipid fractions. Specific activities of plasma and liver phospholipids were about 50% greater in epinephrine-injected rabbits while the aortic phospholipids turnover was 131% greater than in controls. The possible relationship of the latter finding to the development of arteriosclerosis was discussed.