Clinical Appraisal of Hexamethonium (C6) in Peripheral Vascular Diseases
- 30 August 1951
- journal article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 245 (9), 325-328
- https://doi.org/10.1056/nejm195108302450903
Abstract
SINCE Paton and Zaimis1 suggested the clinical potentialities and demonstrated the ganglion-blocking properties of pentamethonium (C5) and hexamethonium (C6), much interest has centered on these compounds. Studies by Arnold and his co-workers,2 using C5, and by Burt and Graham, using C5 and C6,3 demonstrated that these agents are 5 times as potent as tetraethylammonium (TEA). Pentamethonium iodide in doses of 50 mg. given intravenously produced a rise of digital skin temperature with a simultaneous increase in digital blood flow and pulse volume lasting for one to two hours. Studies in this laboratory4 confirmed the observations of these British investigators and . . .Keywords
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