Hemagglutination-Inhibition Antibody Responses in Human Adenovirus Infections

Abstract

Paired sera from 36 children naturally infected with adenovirus types 1, 2, 3, or 5 and from 27 adults naturally infected with adenovirus types 4 or 7 were studied for homotypic and heterotypic hem-agglutination-inhibition (HI) antibodies and for complement-fixing (CF) antibody. Homotypic HI responses were observed in most instances. Heterotypic HI responses were relatively uncommon among the children but occurred in adults with about the same frequency as has been reported for heterotypic neutralizing antibody responses in the same type of population. Significant CF antibody responses were detected in most of the adults but in less than one-half of the children.