One-Trial Interhemispheric Transfer of a Learning Engram

Abstract

By using spreading depression to decorticate temporarily one hemisphere in rats, a learning trace was established in the opposite functional hemisphere. Spontaneous transfer of the engram from the trained hemisphere to the untrained hemisphere does not occur when both hemispheres are functional. If, however, the animal was allowed to make one reinforced response, complete transfer of the engram to the untrained hemisphere occurred.