A weak signal for strong responses: interferon-alpha/beta revisited
Top Cited Papers
- 1 May 2001
- journal article
- review article
- Published by Springer Nature in Nature Reviews Molecular Cell Biology
- Vol. 2 (5), 378-386
- https://doi.org/10.1038/35073080
Abstract
Biological systems have acquired adaptability and robustness against rapid environmental changes. A typical example is the immune system, which eradicates invading pathogens such as viruses. Interferons alpha and beta, which are produced in response to viral infection, are essential components of this system but are also produced at low levels in the absence of infection. What is the purpose of the constitutive weak interferon-alpha/beta signal?Keywords
This publication has 87 references indexed in Scilit:
- Cross talk of the interferon‐α/β signalling complex with gp130 for effective interleukin‐6 signallingGenes to Cells, 2001
- CD8+ T Cell–Mediated Skin Disease in Mice Lacking IRF-2, the Transcriptional Attenuator of Interferon-α/β SignalingImmunity, 2000
- Distinct and Essential Roles of Transcription Factors IRF-3 and IRF-7 in Response to Viruses for IFN-α/β Gene InductionImmunity, 2000
- Cross Talk Between Interferon-γ and -α/β Signaling Components in Caveolar Membrane DomainsScience, 2000
- NATURAL KILLER CELLS IN ANTIVIRAL DEFENSE: Function and Regulation by Innate CytokinesAnnual Review of Immunology, 1999
- The essential role of endogenous IFN α/β in the anti‐metastatic action of sensitized T lymphocytes in mice injected with friend erythroleukemia cellsInternational Journal of Cancer, 1995
- The Molecular Cell Biology of Interferon-gamma and its ReceptorAnnual Review of Immunology, 1993
- Biologic Effects of InterferonsJournal of Investigative Dermatology, 1990
- INTERFERONS AND THEIR ACTIONSAnnual Review of Biochemistry, 1987
- The physiological interferon responseImmunology Today, 1985