Native-like folding intermediates of homologous ribonucleases
- 1 July 1985
- journal article
- research article
- Published by American Chemical Society (ACS) in Biochemistry
- Vol. 24 (15), 3846-3852
- https://doi.org/10.1021/bi00336a005
Abstract
The mechanism of the slow refolding reactions of the 4 different pancreatic ribonucleases from ox, sheep, red deer, and roe deer has been investigated. Refolding kinetics of these proteins were very similar. In particular, a native-like intermediate, IN, was shown to be populated on the slow refolding pathway of all ribonucleases. Similar to the stability of the folded proteins, the pathway of slow refolding has been conserved despite the differences in amino acid sequence and the varying number of proline residues.This publication has 8 references indexed in Scilit:
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