The DAP kinase family of pro‐apoptotic proteins: novel players in the apoptotic game
- 16 March 2001
- Vol. 23 (4), 352-358
- https://doi.org/10.1002/bies.1050
Abstract
The DAP (Death Associated Protein) kinase family is a novel subfamily of pro‐apoptotic serine/threonine kinases. All five DAP kinase family members identified to date are ubiquitously expressed in various tissues and are capable of inducing apoptosis. The sequence homology of the five kinases is largely restricted to the N‐terminal kinase domain. In contrast, the adjacent C‐terminal regions are very diverse and link individual family members to specific signal transduction pathways. There is increasing evidence that DAP kinase family members are involved in both extrinsic and intrinsic pathways of apoptosis and may play a role in tumor progression. This review will focus on structural composition and subcellular localization of DAP kinase family members and on signal transduction pathways leading to their activation. Potential mechanisms of DAP kinase family‐mediated apoptosis will be discussed. BioEssays 23:352–358, 2001. © 2001 John Wiley & Sons, Inc.Keywords
This publication has 48 references indexed in Scilit:
- Interaction partners of Dlk/ZIP kinase: co-expression of Dlk/ZIP kinase and Par-4 results in cytoplasmic retention and apoptosisOncogene, 1999
- C-terminal truncation of Dlk/ZIP kinase leads to abrogation of nuclear transport and high apoptotic activityOncogene, 1999
- DAP-kinase Participates in TNF-alpha and Fas-induced Apoptosis and Its Function Requires the Death DomainThe Journal of cell biology, 1999
- Identification of RIP3, a RIP-like kinase that activates apoptosis and NFκBCurrent Biology, 1999
- Anti-apoptotic versus pro-apoptotic signal transduction: Checkpoints and stop signs along the road to deathOncogene, 1998
- MAP3K-related kinase involved in NF-KB induction by TNF, CD95 and IL-1Nature, 1997
- Induction of Apoptosis by ASK1, a Mammalian MAPKKK That Activates SAPK/JNK and p38 Signaling PathwaysScience, 1997
- Signal Transduction Pathways Regulated by Mitogen-activated/Extracellular Response Kinase Kinase Kinase Induce Cell DeathJournal of Biological Chemistry, 1996
- Opposing Effects of ERK and JNK-p38 MAP Kinases on ApoptosisScience, 1995
- RIP: A novel protein containing a death domain that interacts with Fas/APO-1 (CD95) in yeast and causes cell deathCell, 1995