Cyclosporin A increases survival of cross-species intrastriatal grafts of embryonic dopamine-containing neurons
- 1 September 1985
- journal article
- research article
- Published by Springer Nature in Experimental Brain Research
- Vol. 60 (1), 204-208
- https://doi.org/10.1007/bf00237035
Abstract
Summary The survival and function of cross-species (mouse-to-rat) grafts of fetal mesencephalic dopamine (DA) neurons, implanted as a cell suspension in the striatum of rats with lesions of the mesostriatal DA system, have been studied in animals with and without immunosuppression induced by Cyclosporin A (CyA). At 6 weeks after grafting 3 out of 7 non-CyA treated animals showed some degree of graft survival and variable functional compensation. In those three animals an average of 92 DA neurons per graft was counted. In the grafted animals treated with daily CyA injections, all grafts survived and produced partial or complete functional compensation, and they had an average of 557 DA neurons per graft. It is concluded that intracerebral graft survival and function can be greatly improved by CyA treatment and that the immunological protection of neural transplants in the brain is only partial.Keywords
This publication has 17 references indexed in Scilit:
- Monitoring of cell viability in suspensions of embryonic CNS tissue and its use as a criterion for intracerebral graft survivalBrain Research, 1985
- Cross-species septal transplants: recovery of choline acetyltransferase activityBrain Research, 1984
- Survival of nerve allografts in sensitized rats treated with cyclosporin AJournal of Neurosurgery, 1984
- Intracerebral Neural Implants: Neuronal Replacement and Reconstruction of Damaged CircuitriesAnnual Review of Neuroscience, 1984
- Embryonic neural transplants across a major histocompatibility barrier: survival and specificity of innervationBrain Research, 1983
- Cross-species neural grafting in a rat model of Parkinson's diseaseNature, 1982
- PROLONGATION OF CARDIAC XENOGRAFT SURVIVAL IN RATS RECEIVING CYCLOSPORIN ATransplantation, 1981
- The aluminum-formaldehyde (ALFA) histofluorescence method for improved visualization of catecholamines and indoleamines. 1. A detailed account of methodology for central nervous tissue using paraffin, cryostat or vibratome sectionsJournal of Neuroscience Methods, 1980
- Estimation of nuclear population from microtome sectionsThe Anatomical Record, 1946
- CONDITIONS DETERMINING THE TRANSPLANTABILITY OF TISSUES IN THE BRAINThe Journal of Experimental Medicine, 1923