Activated c-K-ras and c-N-ras oncogenes in 3-methylcholanthrene-induced BALB/c fibrosarcomas
- 1 August 1988
- journal article
- research article
- Published by Oxford University Press (OUP) in Carcinogenesis: Integrative Cancer Research
- Vol. 9 (8), 1517-1519
- https://doi.org/10.1093/carcin/9.8.1517
Abstract
DNAs from fourteen fibrosarcomas induced by 3-methyl-cholanthrene (MCA) in BALB/c mice were analyzed for the presence of transforming oncogenes following transfection on NIH3T3 cells. Six transfection-positive DNAs contained an activated ras gene: four c-K- ras and two c-N- ras . These results demonstrate that c-K- ras is not the only oncogene of the ras family activated in MCA-induced murine fibrosarcomas as was previously indicated.This publication has 16 references indexed in Scilit:
- ras GENESAnnual Review of Biochemistry, 1987
- Direct mutagenesis of Ha-ras-1 oncogenes by N-nitroso-N-methylurea during initiation of mammary carcinogenesis in ratsNature, 1985
- Activation of a c-K- ras Oncogene by Somatic Mutation in Mouse Lymphomas Induced by Gamma RadiationScience, 1984
- A molecular approach to leukemogenesis: mouse lymphomas contain an activated c-ras oncogene.Proceedings of the National Academy of Sciences, 1984
- Induction of mammary carcinomas in rats by nitroso-methylurea involves malignant activation of H-ras-1 locus by single point mutationsNature, 1983
- Identification by transfection of transforming sequences in DNA of human T-cell leukemias.Proceedings of the National Academy of Sciences, 1983
- Frequent Activation of c- kis as a Transforming Gene in Fibrosarcomas Induced by MethylcholanthreneScience, 1983
- The p21 src genes of Harvey and Kirsten sarcoma viruses originate from divergent members of a family of normal vertebrate genesNature, 1981
- Unique transforming gene in carcinogen-transformed mouse cellsNature, 1981
- Dual evolutionary origin for the rat genetic sequences of Harvey murine sarcoma virusJournal of Virology, 1980