Cycloaddition reactions of oximes; powerful new carbon–carbon bond forming methodology

Abstract

Oximes react with Michael acceptors and dipolarophiles, usually regio- and stereo-specifically, via a tandem Michael addition–1,3-dipolar cycloaddition process, to give isoxazolidines in good yield; analysis of the tandem process identifies four broad synthetic variants, and examples of those involving initial intermolecular Michael addition are given.