CL1-SR39: A Noninvasive Molecular Imaging Model of Prostate Cancer Suicide Gene Therapy Using Positron Emission Tomography
- 1 September 2002
- journal article
- Published by Wolters Kluwer Health in Journal of Urology
- Vol. 168 (3), 1193-1198
- https://doi.org/10.1016/s0022-5347(05)64624-1
Abstract
Conclusions Molecular based imaging of sr39tk transfected prostate cancer tumors and adenoviral delivered HSV1-tk suicide gene therapy based on the selective conversion and intracellular trapping of 18 F-FHBG by sr39tk is feasible. Potential applications include noninvasive monitoring of the location, duration and intensity of gene constructs, which may contribute to the safety of clinical gene therapy protocols, and noninvasive imaging of the prostate cancer xenograft response to experimental therapy.This publication has 17 references indexed in Scilit:
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