The Metabolism of [14C] O,O-Diethyl O-(3,5,6-trichloro-2-pyridyl)phosphorothioate (Dursban) in Fish1

Abstract

The new Dursban® insecticide is effective in controlling mosquitoes. The active ingredient of this insecticide is O, O-diethyl O-(3,5,6-trichloro-2-pyridyl) phosphorothioate. In spraying Dursban to control mosquitoes, the chemical will come in contact with the fish, plants, and soil in the environment. In investigations with [¹⁴C] labeled insecticide, it was found that the Dursban is rapidly absorbed from the water by plants and soil particles, but very slowly metabolized. Fish absorb the compound at a much slower rate, but rapidly metabolize it. The detoxified products are then eliminated into the water. Under natural conditions the majority of the Dursban will be absorbed by the plants and soil particles thus limiting the amount which can be taken up by the fish.