The adrenal venous output of 17-hydroxycorticosteroids and catechol amines was measured in the basal state and following burn trauma in a series of dogs with their brains removed. The brain above the inferior colli-culus was removed, leaving the pituitary in situ. For as long as five days after brain removal, such animals revealed high resting levels of corticoids and two-thirds of the animals responded to burn trauma with increased outputs of corticosteroids. Low resting levels of catechol amine output were observed in the dogs with isolated pituitaries, with normal increased response following burns.