Can Cervical Dysplasia and Cs Nutrients?
- 27 April 2009
- journal article
- research article
- Published by Oxford University Press (OUP) in Nutrition Reviews
- Vol. 56 (1), 9-16
- https://doi.org/10.1111/j.1753-4887.1998.tb01653.x
Abstract
Invasive cervical cancer accounts for 11.6% of all cancers worldwide and is the second most common cancer among women. It is the most common cancer among women living in less developed countries. Although infection with oncogenic-type human papillomaviruses (HPV) is associated with most cases of cervical cancer, HPV infection alone is an insufficient cause of cervical cancer. Research from the last two decades suggests a role for nutrients in the prevention of cervical cancer. However, results from phase III folic acid and beta-carotene chemoprevention trials have been negative. Potential reasons for the lack of treatment effect are discussed within the context of cervical carcinogenesis.Keywords
This publication has 43 references indexed in Scilit:
- Effects of β-Carotene and Other Factors on Outcome of Cervical Dysplasia and Human Papillomavirus InfectionGynecologic Oncology, 1997
- Effects of a Combination of Beta Carotene and Vitamin A on Lung Cancer and Cardiovascular DiseaseNew England Journal of Medicine, 1996
- Prevention of Carcinoma In Situ of Human Papillomavirus Type 16-Immortalized Human Endocervical Cells by Retinoic Acid in Organotypic Raft CultureObstetrics & Gynecology, 1995
- Enhancement of Regression of Cervical Intraepithelial Neoplasia II (Moderate Dysplasia) With Topically Applied All- trans -Retinoic Acid: a Randomized TrialJNCI Journal of the National Cancer Institute, 1994
- Cervical Dysplasia Regression Induced by All- trans -Retinoic AcidJNCI Journal of the National Cancer Institute, 1994
- Estimates of the worldwide incidence of eighteen major cancers in 1985International Journal of Cancer, 1993
- The Effect of DNA Methylation on Gene Regulation of Human PapillomavirusesJournal of General Virology, 1993
- Recent Progress in Defining the Epidemiology of Human Papillomavirus Infection and Cervical NeoplasiaJNCI Journal of the National Cancer Institute, 1992
- Hydrogen peroxide causes amplification of viral and cellular genesFree Radical Biology & Medicine, 1990