Trisodium Phosphonoformate Inhibits Hepatitis B Dane Particle Dna Polymerase
- 1 September 1979
- journal article
- research article
- Published by Wiley in Acta Pathologica Microbiologica Scandinavica Section B Microbiology
- Vol. 87B (1-6), 75-76
- https://doi.org/10.1111/j.1699-0463.1979.tb02406.x
Abstract
Evidence available indicates that the so-called Dane particles are the hepatitis virus. A DNA polymerase is associated with the core of these particles. The probability that this is the viral DNA polymerase offers the possibility of preventing hepatitis B multiplication by selective inhibition of this enzyme. This investigation reports that trisodium phosphonoformate (PFA) at low concentrations but not phosphonoacetate acid (PAA) inhibits Dane particle associated DNA polymerase.Keywords
This publication has 13 references indexed in Scilit:
- Therapeutic Effect of Trisodium Phosphonoformate on Cutaneous Herpesvirus Infection in Guinea PigsAntimicrobial Agents and Chemotherapy, 1978
- Trisodium Phosphonoformate, a New Antiviral CompoundScience, 1978
- Inhibition of Herpesvirus Replication and Herpesvirus-Induced Deoxyribonucleic Acid Polymerase by PhosphonoformateAntimicrobial Agents and Chemotherapy, 1978
- Inhibition of hepatitis B DNA polymerase by intercalating agentsNature, 1978
- Mode of inhibition of Herpes simplex virus DNA polymerase by phosphonoacetateBiochemistry, 1975
- Dane Particles, DNA Polymerase, and e-Antigen in Two Different Categories of Hepatitis B Antigen CarriersIntervirology, 1975
- D.N.A. POLYMERASE IN PREPARATIONS CONTAINING AUSTRALIA ANTIGENThe Lancet, 1971
- VIRUS-LIKE PARTICLES IN SERUM OF PATIENTS WITH AUSTRALIA-ANTIGEN-ASSOCIATED HEPATITISThe Lancet, 1970
- Beitrag zur Kenntnis der organischen PhosphorverbindungenBerichte der deutschen chemischen Gesellschaft (A and B Series), 1924