Abstract
The past 2 decades have witnessed an explosion in molecular neurogenetics and neurobiology. The aggres sive application of new techniques to the dominantly inherited disorder, Huntington's disease, defined the standard for the positional cloning of human genetic diseases. A parallel effort from neurobiologists and clinicians has set the stage for the development of potential new therapies for the disease. Along the winding road to finding the gene, many lessons were learned by clinicians and scientists alike. The next decade of research offers new challenges and rewards for those involved with this disease. The Neuroscientist 1:51- 58, 1995