A Modified Polyriboinosinic-Polyribocytidylic Acid Complex That Induces Interferon in Primates

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Abstract
A complex of polyriboinosinic-polyribocytidylic acid (poly I · poly C) with poly-tlysine and carboxymethylcellulose has been prepared. This complex is five to 10 times as resistant to hydrolysis by primate serum as the parent poly I · poly C. It has a thermal denaturation temperature about 40 C higher than that of poly I · poly C. The complex induces significant levels of serum interferon in monkeys and chimpanzees under conditions in which poly I · poly C itself induces no interferon.