Effects of Estradiol and Progesterone on Epidermal Growth Factor Concentration in Plasma, Bile, Urine, Submandibular Gland and Kidney of the Mouse
- 1 January 1989
- journal article
- research article
- Published by S. Karger AG in Hormone Research
- Vol. 31 (3), 143-147
- https://doi.org/10.1159/000181104
Abstract
Testosterone is known to increase epidermal growth factor (EGF) concentrations in mouse plasma and submandibular salivary gland. We tested in adult sialoadenectomized (sx) and sham-operated female and male mice our hypothesis that female sex steroids also affect EGF concentrations in fluids and tissues. In 10-day treatment estradiol-17β increased the EGF concentration in male urine and in (sx) female plasma. Progesterone increased the concentration in both sexes in plasma (sx mice) and in the kidneys. In contrast, progesterone decreased it in female urine.Keywords
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