Amino-acids and peptides. Part 21. Synthesis of a congener of the cyclohexadepsipeptide antibiotic, monamycin

Abstract

The hexadepsipeptide H-D-Val-L-IIa-(R)-Pip-(S)-Pip-NMe-D-Leu-L-Pro-OH has been prepared and cyclised to give the unnatural congener (I, X) of monamycin. It has antibacterial properties.