With the color technique for radioisotope scanning, gold Au 198 scans of the liver were correlated with the pathological findings in 116 patients. Scans were interpreted as being positive for space-occupying lesions in 46 patients, of whom 41 were proved to have metastases. In 70 patients, the scan was interpreted as showing no evidence of space-occupying lesions. This diagnosis was borne out pathologically in all but one patient. Since each color represents a given percentage of radioactivity, it is possible to interpret the color scan in a semiquantitative manner. Space-occupying lesions of the liver, indicated by areas of reduced radioactivity, can be easily identified on the scan. It is suggested that the close correlation between the scan and pathological findings is due to more objective evaluation of semiquantitative data when the color technique is used.