Action of Butyltolylsulfonylurea on Liver Glycogenolysis.

Abstract

In fasted rats butyltolylsulfonylurea (BTSU) produced hypoglycemia and decreased liver glycogenolysis. In rats fed only glucose, it produced hypoglycemia, but the amount of liver glycogen was comparable to that in untreated glucose-fed rats. After treatment of rabbits with BTSU for 4 days, the spontaneous glucose output from liver slices was less than that from liver slices of control animals. The formation of inorganic phosphate by liver homogenate in the presence of glucose-6-phosphate was less in the BTSU-treated rats than in control rats, thus indicating lower glucose-6-phos-phatase activity. Apparently BTSU produces hypoglycemia at least partially by decreasing the glucose-6-phosphatase activity of the liver.