THROMBOTIC THROMBOCYTOPENIC PURPURA: A REVIEW OF THE LITERATURE WITH REPORT OF A CASE

Abstract

This is an analysis of 63 cases of thrombotic thrombocytopenic purpura reported in the literature. This study outlines the pathologic characteristics, prognosis, prodromata, and physical findings of the disease. The diagnosis should be suspected by the triad of severe hemolytic anemia, thrombocytopenic purpura, and fluctuating neurologic changes. Confirmatory diagnosis can be made only by finding the characteristic hyaline vascular abnormalities at the arterio-capillary junction. Biopsies of various tissue is discussed. At the present time paraffin studies of the bone marrow seem most promising. Therapy has been disappointing. Further trial of spelectomy and steroids is advised, both as early as possible. The etiology of the disease is analysed at length. An antigen-antibody response to a sensitizing agent is the most likely cause of thrombotic thrombocytopenic purpura. The reported case added to the literature developed the disease in a fulminating form only 3 days after receiving an influenza immunization.