USE OF TRICATECHOLAMIDE LIGANDS TO ALTER THE BIODISTRIBUTION OF GA-67 - CONCISE COMMUNICATION

Abstract

The effect of the i.v. administration of the synthetic siderophore LICAM-C [N,N''N''''-tris(2,3-dihydroxy-4-carboxybenzoyl)-1,5,10-triazadecane] on the biodistribution 67Ga was investigated in rats. The ligand was capable of in vivo complexing with 67Ga, which hastened the renal clearance of the nuclide. The Ga concentration was decreased in all organs, with the exception of the liver and spleen, where hydroxide, precipitates may interfere with Ga sequestration by LICAM-C. The Ga in abscess tissue was only slightly affected, giving rise to an increase in the 67Ga abscess-to-soft-tissue concentration ratio when LICAM-C is administered. Dosimetry calculations show that the siderophore decreases the radiation burden from 67Ga citrate. The advantages of clinical application of LICAM-C are discussed. [The in vivo affinity of 67Ga complexes for abscesses and various types of soft-tissue and bony tumors has led to the prevalent use of this radionuclide in nuclear medicine.].