THE OCCURRENCE of abnormal globulins in a variety of diseases is well recognized and is often helpful in establishing a diagnosis. Recently, attention has been drawn to fibrinogen abnormalities in relation to several pathologic states. This report presents an instance of marked, persisting hyperfibrinogenemia and reversible "cryocoagulation" of heparinized blood in a patient with undiagnosed disease for a period of years and without any clinical or pathologic evidence of thrombotic or hemorrhagic phenomena. At postmortem examination an unsuspected clear cell adenocarcinoma of the left kidney was found. Report of a Case A 58-year-old white woman was admitted to Goldwater Memorial Hospital for the first time on Nov. 1, 1960, with complaints of weakness and weight loss of about 3½ years' duration. During this period, she was hospitalized elsewhere on 3 occasions but no definite diagnosis was established. Treatment included prolonged steroid therapy, tolbutamide to control complicating hyperglycemia, streptomycin, isoniazid (Inh),