The Susceptibility of Five Inbred Strains of Mice to Liver Changes Induced by Subcutaneous Injection of 2-Amino-5-Azotoluene

Abstract

Mice of strains A, C, C3H, I, and Y were injected subcut. with 10 mg. of commercial 2-amino-5-azotoluene each mo. for 11 mos. According to the macroscopic appearance of the livers, mice of strain C were the most susceptible and mice of strain Y the most resistant to the action of the compound. Mice of strain A were more susceptible than those of strain C3H. Since strain C3H animals were more susceptible to spontaneous hepa-toma than those of strain A, the results suggested that in these strains susceptibility to liver growths induced by 2-amino-5-azotoluene was not correlated with susceptibility to spontaneous hepatoma.