Effect of Exposure to Cold on Some Aspects of Hepatic Acetate Utilization

Abstract

Liver slices were prepared from control rats kept at 25[degree]C and "cold" rats exposed to 0-2[degree]C for 1, 2, 5 and 10 days and were incubated in a buffer solution containing sodium acetate-l-C14. The ability of liver from 1-and 2-day "cold" rats to synthesize fatty acid from acetate was markedly depressed. However, after exposure of animals to cold for 5 or 10 days adaptation occurred with a return to almost normal lipogenesis. There is apparently a causal relationship between the depressed lipogenesis and low liver carbohydrate. Effects on acetate oxidation and cholesterogenesis from acetate are also reported and discussed.