Split of HLA‐D into Two Regions α and β by a Recombination between HLA‐D and GLO. I. Study in a Family and Primed Lymphocyte Typing for Determinants Coded by the β Region

Abstract

In a family with a paternal recombinant child [in chromosome 6] between HLA-D/Dr and GLO [glyoxylase], PLT (primed lymphocyte testing reagents) were raised between HLA-A-B-C-D-DR and Bf [properdin factor B] identical sibs. Since these sibs differ only within a region (.beta.) between HLA-D/DR and GLO and the centromere, these PLT allow the typing of 2 new determinants differing from HLA-D/DR, possibly alleles at a new locus mapping in a region outside HLA-D/DR. A difference limited to this .beta. region can induce a weak primary and a strong secondary MLR (mixed leukocyte response).