Synthesis and characterisation of some new diazopeptides

Abstract

The synthesis of eight new diazopeptides by aprotic diazotisation with N₂O₄ is described for glycylglycine, triglycine, pentaglycine, L-leucylglycine and the ethyl esters of L-leucylglycine, L-alanylglycine, L-serylglycine and L-threonylglycine. The diazo derivatives (7)–(10) of the parent peptides are isolated as calcium salts. The UV-vis., IR, ¹H NMR and MS properties of the new diazopeptides are reported together with those for the diazo derivative of glycylglycine ethyl ester and glycylglycinamide.