Re-evaluation of the effect of ellagic acid on dimethylnitrosamine mutagenicity
- 1 January 1989
- journal article
- research article
- Published by Oxford University Press (OUP) in Mutagenesis
- Vol. 4 (6), 453-455
- https://doi.org/10.1093/mutage/4.6.453
Abstract
Dimethylnitrosamine (DMN) is activated to mutagenic species in the Ames test (Salmonella typhimurium strain TA 100) by hamster hepatic S9 preparation. This S9 activity is induced by administration of ethanol to the animals. The organic solvents dimethylsulphoxide (DMSO) and N-methyl-2-pyrrolidinone (MP) inhibit this mutagenicity, apparently because they inhibit DMN demethylase activity (assayed as formaldehyde production). Ellagic acid, dissolved in DMSO or MP, had no inhibitory effect on DMN mutagenicity, beyond the effect of the solvent vehicle.This publication has 12 references indexed in Scilit:
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