Nonspecific complement activation by streptococcal structures. I. Re-evaluation of HLA cytotoxicity inhibition.
Open Access
- 1 June 1976
- journal article
- research article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 143 (6), 1341-1351
- https://doi.org/10.1084/jem.143.6.1341
Abstract
A number of experiments have suggested that there is an antigenic relationship between the HLA complex and streptococcal bacterial structures. Using inhibition of cytotoxicity of HLA antisera as our assay system, it was demonstrated that the inhibitory effect on HLA cytotoxicity by streptococcal antigens is, in reality, due to activation and consumption of components of the alternate complement pathway. In addition, antisera prepared against streptococcal membrane antigens had no cytotoxic effect on a large panel of human lymphocytes, nor did these antisera exhibit immunofluorescent staining of lymphocytes directly. These experiments are compatible with our concept that the HLA complex may have evolved through selective evolutionary pressure as a means of escaping bacterial mimicry.This publication has 14 references indexed in Scilit:
- Nonspecific complement activation by streptococcal structures. II. Properdin-independent initiation of the alternate pathway.The Journal of Experimental Medicine, 1976
- PURIFICATION AND PHYSICAL PROPERTIES OF GROUP C STREPTOCOCCAL PHAGE-ASSOCIATED LYSINThe Journal of Experimental Medicine, 1971
- Rejection of skin allografts by irradiation chimeras: evidence for skin-specific transplantation barrier.1971
- Cross-Reactions between Streptococcal M Proteins and Human Transplantation AntigensScience, 1970
- In Vitro Detection of Transplantation Immunity: The Inhibition of Migration of Immune Spleen Cells and Peripheral Blood Leukocytes by Specific AntigenThe Journal of Immunology, 1970
- Isolation of mononuclear cells and granulocytes from human blood. Isolation of monuclear cells by one centrifugation, and of granulocytes by combining centrifugation and sedimentation at 1 g.1968
- Microdroplet Assay of Human Serum CytotoxinsNature, 1964
- Homograft Sensitivity Induction by Group A StreptococciScience, 1964
- STUDIES OF L FORMS AND PROTOPLASTS OF GROUP A STREPTOCOCCIThe Journal of Experimental Medicine, 1959
- A new culture medium for the production of antigenic streptococcal hæmolysinThe Journal of Pathology and Bacteriology, 1932