HIDDEN IGG ANTIGLOBULINS IN NORMAL HUMAN-SERUM

  • 1 January 1976
    • journal article
    • research article
    • Vol. 25 (2), 185-190
Abstract
Hidden antiglobulins reacting with whole rabbit immunoglobulin [Ig] were found by radioassay or indirect hemagglutination after gel filtration or ultracentrifugation of normal serum. IgM and IgG antiglobulins were present in the same macroglobulin fractions. The IgG antiglobulins could be dissociated into 7S components by separating the serum under acid conditions. Antiglobulin activity was a function of the Fab region.