First Artificial Receptors and Chemosensors toward Phosphorylated Peptide in Aqueous Solution
- 9 May 2002
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of the American Chemical Society
- Vol. 124 (22), 6256-6258
- https://doi.org/10.1021/ja025761b
Abstract
The first fluorescent chemosensors toward a native phosphorylated peptide are successfully synthesized. Dinuclear zinc(II)-dipicolylamine-based anthracene (1, 2) can selectively recognize and sense phosphorylated species with an increase in the fluorescence intensity. We also demonstrated that these artificial receptors fluorometrically detect a phosphorylated peptide with high affinity (>107 M-1) in aqueous solution.Keywords
This publication has 23 references indexed in Scilit:
- Introduction: Protein Phosphorylation and SignalingChemical Reviews, 2001
- Fluorescent Sensors for Zn2+Based on a Fluorescein Platform: Synthesis, Properties and Intracellular DistributionJournal of the American Chemical Society, 2001
- Anion Recognition and Sensing: The State of the Art and Future PerspectivesAngewandte Chemie International Edition, 2001
- Post-photoaffinity labeling modification using aldehyde chemistry to produce a fluorescent lectin toward saccharide-biosensorsChemical Communications, 2001
- Highly Zinc-Selective Fluorescent Sensor Molecules Suitable for Biological ApplicationsJournal of the American Chemical Society, 2000
- A General Semisynthetic Method for Fluorescent Saccharide-Biosensors Based on a LectinJournal of the American Chemical Society, 2000
- Localized Rac Activation Dynamics Visualized in Living CellsScience, 2000
- Phosphate anion binding and luminescent sensing in aqueous solution by ruthenium(II) bipyridyl polyaza receptorsNew Journal of Chemistry, 1999
- Recent development of zinc-fluorophoresChemical Society Reviews, 1998
- Signaling Recognition Events with Fluorescent Sensors and SwitchesChemical Reviews, 1997