In recent years increasing numbers of case reports of human pasteurellosis have appeared in the medical literature. The purpose of our report is to draw attention to a case of pulmonary abscess with empyema caused by Pasteurella multocida. A 63-year-old Negro man, with years of occupational exposure to animals, had an antecedent history of productive cough, hemoptysis, and chronic histoplasmosis. He died 72 lir. after admission to the hospital. Prior to death five strains of P. multocida were cultured from sputum specimens and aspirated empyema fluid. All strains were nonmotile, bipolar staining, Gram-negative bacilli. Distinguishing characteristics included: fermentaton of dextrose, sucrose, and mannitol with production of acid only, production of indole, growth on infusion agar in the absence of X and V factors, and inhibition of growth on desoxycholate agar. In vitro, all strains were susceptible to kanamycin, cephalothin, loridine, tetracycline, and chloramphenicol, and resistant to penicillin, ampicillin, dihydrostreptomycin, and polymyxin B.