EXCRETION OF COPROPORPHYRIN IN HEPATIC DISEASE
- 1 April 1942
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of Internal Medicine
- Vol. 69 (4), 573-581
- https://doi.org/10.1001/archinte.1942.00200160024003
Abstract
Porphyrins are red pigment substances, the chemical structure of which is based on a ring formed by four pyrrole nuclei which are connected in the form of a closed system by four methine bridges. It has long been recognized1 that small amounts of porphyrin are excreted normally in the urine of healthy persons and that these amounts may be increased in the urine of patients suffering from a variety of diseases. Porphyrinuria (increased proportion of porphyrin in the urine) has been described as accompanying many forms of hepatic disease,2 including cinchophen hepatitis, atrophic cirrhosis, obstructive jaundice, chronic passive congestion, lymphosarcoma of the liver, infectious icterus, melanosarcoma of the liver, hemolytic icterus and hemochromatosis. It has been suggested that porphyrinuria observed in the presence of various other diseases and toxic states is caused by associated hepatic damage or dysfunction.3 Much evidence has accumulated which would indicate that porphyrinThis publication has 3 references indexed in Scilit:
- THE URINARY/FECAL COPROPORPHYRIN RATIO IN LIVER DISEASEJCI Insight, 1941
- THE METABOLISM OF BLOOD PIGMENTS IN PERNICIOUS ANEMIAJCI Insight, 1938
- Transformation of haemins into bile pigmentsBiochemical Journal, 1935