Susceptibility to Polymyxin B of Penicillin G-induced Proteus mirabilis L Forms and Spheroplasts
- 1 May 1969
- journal article
- Published by American Society for Microbiology in Journal of Bacteriology
- Vol. 98 (2), 347-350
- https://doi.org/10.1128/jb.98.2.347-350.1969
Abstract
A polymyxin B-resistant strain of Proteus mirabilis was converted into L forms and spheroplasts in the presence of penicillin G. This treatment caused a 400-fold increase in polymyxin B susceptibility. The acquired susceptibility was in the range of the natural susceptibility reported for susceptible gram-negative bacteria (∼1 μg/ml). The high susceptibility to polymyxin B was lost as soon as the spheroplasts and L forms were allowed to reconvert into the bacillary form in penicillin-free media. This behavior is strong evidence that the natural resistance of Proteus strains to polymyxins is due to the impermeability of the outer cell wall structures to these antibiotic substances.Keywords
This publication has 13 references indexed in Scilit:
- The cyclic phosphodiesterases (3'-nucleotidases) of the EnterobacteriaceaeBiochemistry, 1968
- The 5'-nucleotidases (uridine diphosphate sugar hydrolases) of the EnterobacteriaceaeBiochemistry, 1968
- Selective Release of Enzymes from BacteriaScience, 1967
- Chemical, Biological, and Structural Properties of StableProteusL Forms and Their Parent BacteriaJournal of Bacteriology, 1967
- EFFECTS OF ANTIBIOTICS ON PROTOPLAST AND BACTERIAL FORMS OF STREPTOCOCCUS FAECALIS1966
- Susceptibility of Proteus mirabilis and its Stable L-Forms to Erythromycin and Other MacrolidesNature, 1962
- [Antibacterial spectra of colistine for 1200 strains].1961
- The properties and mode of action of the polymyxins.1956
- [Comparative sensitivity of normal and L forms of two strains of Proteus to some antibiotics].1952
- [Biochemical research on the mode of action of polymyxin].1950