Synaptosomal accumulation of intracerebral injected amino acids
- 1 February 1979
- journal article
- research article
- Published by Wiley in Acta Physiologica Scandinavica
- Vol. 105 (2), 156-162
- https://doi.org/10.1111/j.1748-1716.1979.tb06327.x
Abstract
The distribution of the labels of [35S]taurine, [3H]lysine, [14C]glutamate and [14C]norleucine in mouse brain subcellular fractions was followed after intracerebral injection in vivo. [35S]taurine, [3H]lysine and [14C]glutamate and its metabolites accumulated in the nerve terminals, lysine and glutamate also occurring in the synaptic vesicles, while taurine remained mainly in the soluble synaptoplasm. [14C]norleucine penetrated the brain cell membranes slowly, but was still bound to the synaptic vesicles to a greater extent than taurine.Keywords
This publication has 21 references indexed in Scilit:
- COMPARATIVE STUDIES ON THE DEGRADATION OF GABA and TAURINE IN THE BRAINJournal of Neurochemistry, 1978
- Physicochemical Characterization of Taurine Binding with Synaptic Membranes in the Chicken BrainInternational Journal of Neuroscience, 1978
- A Peptide Containing Aspartic Acid, Glutamic Acid and Serine in Calf Brain Synaptic Vesicles.Acta Chemica Scandinavica, 1977
- Pig brain 4-aminobutyrate 2-ketoglutarate transaminase. Purification, kinetics and physical propertiesBiochimie, 1974
- Amino acid transmitters in the mammalian central nervous systemErgebnisse der Physiologie, Biologischen Chemie und Experimentellen Pharmakologie, 1974
- AMINO ACIDS IN SYNAPTIC VESICLES FROM MAMMALIAN CEREBRAL CORTEX: A REAPPRAISALJournal of Neurochemistry, 1973
- UPTAKE AND RELEASE OF TAURINE FROM RAT BRAIN SLICESJournal of Neurochemistry, 1972
- Amino Acid TransportPublished by Springer Nature ,1972
- METABOLITES OF [3H]ACETATE BOUND TO SYNAPTIC VESICLES ISOLATED FROM RAT CEREBRAL CORTEXJournal of Neurochemistry, 1971
- PHARMACOLOGICAL EFFECTS PRODUCED BY INTRACEREBRAL INJECTION OF DRUGS IN THE CONSCIOUS MOUSEBritish Journal of Pharmacology and Chemotherapy, 1957