9-Nor-9-hydroxyhexahydrocannabinols. Synthesis, some behavioral and analgesic properties, and comparison with the tetrahydrocannabinols
- 1 September 1976
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 19 (9), 1165-1167
- https://doi.org/10.1021/jm00231a017
Abstract
The racemic mixture and levo isomer of both 9-nor-9.alpha.-hydroxyhexahydrocannabinol and its 9.beta.-hydroxy isomer were prepared. Both .alpha.- and .beta.-hydroxy compounds were active in the dog ataxia test and depressed spontaneous activity in mice. Only the .beta.-hydroxy compound was an analgesic in mice with morphine-like potency. The behavioral and analgesic properties of these compounds may be mediated through different sites or mechanisms and may, therefore, be separable.This publication has 2 references indexed in Scilit:
- Structures Related to Morphine. XXXI.1 2'-Substituted BenzomorphansJournal of Medicinal Chemistry, 1965
- SYNTHETIC ANALGESICS .2. DITHIENYLBUTENYLAMINES AND DITHIENYLBUTYLAMINES1953