Activation-induced restoration of sensorimotor functions in rats with dopamine-depleting brain lesions.

Abstract

Bilateral electrolytic lesions of the lateral hypothalamus or intraventricular 6-hydroxydopamine injections produced substantial depletions of striatal dopamine in rats. All animals with brain damage showed marked sensorimotor impairments. They began to move and respond appropriately to environmental stimuli when placed in a sink of water, in a shallow ice bath or among a colony of cats or rats. A reversal of the sensorimotor dysfunctions was still apparent shortly after the animals were removed from each activating situation. The therapeutic effects dissipated rapidly, and by 4 h after an exposure the rats responded as poorly as they had prior to activation. These findings are strikingly similar to the paradoxical kinesia seen in parkinsonism, a clinical disorder attributed to degeneration of central dopamine-containing neurons. Collectively, they suggest the importance of activation in maintaining responsiveness to senory stimuli in rats following dopamine-depleting brain lesions.