ROSETTE FORMATION AND INHIBITION IN CERVICAL DYSPLASIA AND CARCINOMA INSITU

Abstract

Total and early sheep erythrocyte rosettes and rosette inhibition were measured in patients with cervical dysplasia and carcinoma in situ. Total and early rosettes were significantly depressed in patients with carcinoma in situ; early rosettes were also significantly lower than controls in women with severe dysplasia. Rosette inhibition titers were increased in most patients with moderate dysplasia and in all patients with severe dysplasia or carcinoma in situ. The rosette inhibition test may be useful in detecting, in a precancerous state, patients at risk for cancer.