Prognostic factors in adenocarcinoma of the uterine cervix
- 15 April 1986
- Vol. 57 (8), 1584-1593
- https://doi.org/10.1002/1097-0142(19860415)57:8<1584::aid-cncr2820570825>3.0.co;2-8
Abstract
A group of 136 female patients with adenocarcinoma of the uterine cervix, treated at Memorial Sloan-Kettering Cancer Center between 1949 and 1981, with slides available for review, formed the basis for this study. They ranged in age from 10 to 91 years. Most (73%) had abnormal bleeding, either alone or in combination with other symptoms; 15% were asymptomatic. Eighty percent had a visible abnormality, most commonly an exophytic mass. Clinical stages were: 0 (3%), IB (61%), IIA (14%), IIB (10%), III (4%). There were four major histologic subtypes: mucinous (47%), endometrioid (24%), adenosquamous (15%), and clear cell (9%) carcinoma. Of the many clinicopathologic variables evaluated for prognosis, the most significant was stage of disease (P< 0.0001). Those with Stage IB disease had a survival probability of 76% at 5 years compared with 49% for those with Stage IIA and 34% with Stage IIB. The endometrioid pattern was associated with a more favorable prognosis than any other histologic subtype (P = 0.02). The presence of lymphatic tumor emboli and/or metastatic carcinoma in any lymph node group was associated with a less favorable prognosis for patients with Stage IB and IIA disease (P < 0.0001). Cancer 57:1584–1593, 1986.This publication has 28 references indexed in Scilit:
- Childhood nonovarian female genital tract cancers in Britain, 1962-1978. Descriptive epidemiology and long-term survivalCancer, 1984
- Primary adenocarcinoma of the uterine cervix. A clinical studyCancer, 1983
- Extremely Well-Differentiated Adenocarcinoma (“Adenoma Malignum”) of the CervixInternational Journal of Gynecological Pathology, 1983
- Adenocarcinoma of the uterine cervixGynecologic Oncology, 1982
- Epidemiological differences between adenocarcinoma and squamous cell carcinoma of the uterine cervixGynecologic Oncology, 1980
- Invasive cervical carcinoma in young womenGynecologic Oncology, 1979
- ADENOCARCINOMA OF THE UTERINE CERVIX A CLINICAL AND PATHOLOGICAL APPRAISALBJOG: An International Journal of Obstetrics and Gynaecology, 1976
- Asymptotically Efficient Rank Invariant Test ProceduresJournal of the Royal Statistical Society. Series A (General), 1972
- Mesonephric carcinoma of the cervix uteri: A clinical and pathologic studyAmerican Journal of Obstetrics and Gynecology, 1966
- Nonparametric Estimation from Incomplete ObservationsJournal of the American Statistical Association, 1958