Pathogenesis of Crohn's disease
Open Access
- 2 April 2015
- journal article
- review article
- Published by H1 Connect in F1000Prime Reports
- Vol. 7 (44), 44
- https://doi.org/10.12703/p7-44
Abstract
Significant progress in our understanding of Crohn's disease (CD), an archetypal common, complex disease, has now been achieved. Our ability to interrogate the deep complexities of the biological processes involved in maintaining gut mucosal homeostasis is a major over-riding factor underpinning this rapid progress. Key studies now offer many novel and expansive insights into the interacting roles of genetic susceptibility, immune function, and the gut microbiota in CD. Here, we provide overviews of these recent advances and new mechanistic themes, and address the challenges and prospects for translation from concept to clinic.Keywords
This publication has 100 references indexed in Scilit:
- Highlighting new phylogenetic specificities of Crohnʼs disease microbiotaInflammatory Bowel Diseases, 2011
- Defective Hepatic Autophagy in Obesity Promotes ER Stress and Causes Insulin ResistanceCell Metabolism, 2010
- Virus-Plus-Susceptibility Gene Interaction Determines Crohn's Disease Gene Atg16L1 Phenotypes in IntestineCell, 2010
- Induction of Intestinal Th17 Cells by Segmented Filamentous BacteriaCell, 2009
- Specific Microbiota Direct the Differentiation of IL-17-Producing T-Helper Cells in the Mucosa of the Small IntestineCell Host & Microbe, 2008
- XBP1 Links ER Stress to Intestinal Inflammation and Confers Genetic Risk for Human Inflammatory Bowel DiseaseCell, 2008
- Interleukin-23 Restrains Regulatory T Cell Activity to Drive T Cell-Dependent ColitisImmunity, 2008
- The p47 GTPase Lrg-47 (Irgm1) Links Host Defense and Hematopoietic Stem Cell ProliferationCell Stem Cell, 2008
- Autophagy in the Pathogenesis of DiseaseCell, 2008
- Communicable Ulcerative Colitis Induced by T-bet Deficiency in the Innate Immune SystemCell, 2007